Article Subject
Chemistry
Abstract

Nalidixic acid is the first of the synthetic quinolone antibiotics. In the technical sense, it is a naphthyridone, not a quinolone: its ring
structure is a 1,8-naphthyridines nucleus that contains two nitrogen atoms, unlike quinoline, which has a single nitrogen
atom.[1]Synthetic quinolone antibiotics were discovered by George Lesher and coworkers as a byproduct of chloroquine manufacture
in the 1960s.[1] Nalidixic acid is effective against both gram-positive and gram-negative bacteria. In lower concentrations, it acts in
a bacteriostatic manner; that is, it inhibits growth and reproduction. In higher concentrations, it is bactericidal, meaning that it kills
bacteria instead of merely inhibiting their growth.

Keywords
quinolone
naphthyridone
Bacteriostatic
inhibiting
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