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The present study was aimed at evaluating the antifertility effect of phyllanthus amarus extract in male wistar rats. The body and organ weights, cauda epididymal sperm parameters, serum levels of male reproductive hormones and fructose were assessed. Daily oral doses of the extract were administered to each animal in three different test groups for 28 consecutive days. Results show significant (p<0.05) dose dependent decrease in the levels of testosterone, leuteinising hormone, sperm motility, sperm count and sperm viability of the treated animals when compared with the control; while follicle stimulating hormone significantly (p<0.05) increased dose dependently. These findings suggest that the aqueous crude extract of phyllanthus amarus has anti-fertility activity.

phyllanthus amarus
reproductive hormones
sperm parameters.
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