Synthesis, Biological Activity and Docking Studies of N,N'-(3s,4s)- Bis(3,4- Disubstituted Pyrrolidine)-1-Sulfonamide Derivatives as _-Gluscosidase Inhibitors

Starting with L-tartaric acid the chiral 3,4-disubstituted pyrrolidine analogue sulfonamide derivatives were prepared. These compounds were examined for anti-bacterial and anti-fungal activity. Further the docking studies were carried out for the model compounds from each series against -glucosidase and the results found are moderate. The structure–activity relationships are also briefly discussed.