Synthesis, biological activity and docking studies of N,N'-(3S,4S)- bis(3,4-disubstituted pyrrolidine)-1-sulfonamide derivatives as β-gluscosidase inhibitors

Starting with L-tartaric acid the chiral 3,4-disubstituted pyrrolidine analogue sulfonamide derivatives were prepared. These compounds were examined for anti-bacterial and anti-fungal activity. Further the docking studies were carried out for the model compounds from each series against β-glucosidase and the results found are moderate. The structure–activity relationships are also briefly discussed.