Effect of Clitoria Ternatea (Linn) Plant Root Extract on the Neurons of Frontal Cortex and Dentate Gyrus of Young Diabetic Rats – A Preliminary Investigation.

Aim and objective
To study the effect of herbal alcoholic root extract of Clitoria ternatea on the neurons of frontal cortex and dentate gyrus of young
diabetic rats.
Background
The brain is prone for adverse effects of early childhood diabetes which gradually can lead to diabetic encephalopathy. This problem
needs an immediate attention to tackle its advanced adverse effects at the earliest.
Materials and methods
The diabetes was induced in 22 days (postnatal) wistar rats by giving intraperitoneal injection of Streptozotocin at a dose of 60mg/kg
body weight. Daily single dose treatment of 100 mg/kg body weight oral alcoholic root extract of Clitoria ternatea was started and
continued for a month. At the end of treatment, the animals were sacrificed and brain tissue was subjected to histopathological studies.
Results
The data analysis of frontal cortical neurons was expressed as mean+/-SD (standard deviation) and the differences among the groups
were assessed by ANOVA followed by Dunnett test. The number of viable neurons between different experimental groups with p value
0.005 was considered as significant.
Conclusion
The preventive herbal therapy with the alcoholic root extract of Clitoria ternatea has shown a significant effect on the morphology of
neurons of frontal cortex and dentate gyrus.