Possible Treatment of HIV Virus Using Recombinant Monoclonal Antibodies: An Effective Tool against Infectious HIV

Acquired Immune Deficiency Syndrome (AIDS) is an immune disease caused by Human immunodeficiency viruses (HIV). Statisticaldata from World Health Organization (WHO) confirmed death rates of about 25 million people all around the world, there is no proper cure and treatment available for AIDS. In order to eliminate HIV by monoclonal antibody, several epitope regions on HIV were studied and found that conserved regions of gp120 and gp41 glycoproteins are the main cause for antigenicity of HIV that makes them potential target. Human antibody is not able to reach the deep cleft on gp120 and gp41 because of their higher molecular weight and long Yshaped structure. Latest research by scientist show that camelids antibody VHH is smaller, show higher specificity and compete with
soluble CD4 for binding at the gp120 site, leading to new possible light of treatment. In this report, the possible way of treatment of HIV by using a mixture of antibodies from different species has been reported. This mixture of antibodies can more efficiently act on target gp120 site comparing with human antibodies. The proposed mixture of antibodies
has to undergo preclinical and clinical trials before coming into the market.