Abstract

Some new benzodiazepines of chloro quinoline (2-(2-chloro-6-flouroquinoline-3yl)-1H-1,5-Benzodiazepine) have been synthesized and their characterization was done by elemental analysis, IR, NMR and mass spectral data. The solubility data of benzodiazepines derivatives are useful in pharmaceutical industry. Thus, the solubility of synthesized benzodiazepines have been studied in N, N
dimethyl formamide and tetra hydro furan by gravimetrical method from (308.15 to 328.15) K under atmospheric pressure and the solubility data were correlated against temperature. The solubility is found to be greater in DMF than in THF. Further, with increase in temperature, solubility increases in both the solvents.

Issue

The Experiment 2012

Article Subject:

Chemistry

KeyWords:

chloro quinoline, solubility, gravimetrical method, hydro furan

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Shipra Baluja et al, the Experiment, September .2012 Vol.2 (4), 116-129