Abstract

Starting with L-tartaric acid the chiral 3,4-disubstituted pyrrolidine analogue sulfonamide derivatives were prepared. These compounds were examined for anti-bacterial and anti-fungal activity. Further the docking studies were carried out for the model compounds from each series against -glucosidase and the results found are moderate. The structure–activity relationships are also briefly discussed.

Issue

The Experiment 2014

Article Subject:

Chemistry

KeyWords:

L-tartaricacid, pyrrolidine, Docking, -glucosidase

Download PDF:

15.Santosh kumar et al, The Experiment, 2014, Vol. 19(3), 1348-1359